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Stem cells, Exosomes or Platelet Rich Plasma (PRP)?

The use of stem cells, Growth factors, Exosomes and PRP in skin care and aesthetic medicine has generated a lot of excitement. However, there remains a great deal of confusion about the differences between these revolutionary new treatments and other related technologies.

At RÉNOUVEAU Med Spa, Dr. Naeini a Pathologist studding the cell and skin structures on a Molecular level, stays on the cutting edge of technology to provide her West Los Angeles/Brentwood-area patients with the most advanced treatments available in the world. Read on to learn more about these therapies.

IS BIOLOGICAL SKIN AGING A DISEASE?

We would say YES!! Skin aging involves a key disease component simply because not all individuals are similarly impacted, and the consequences of aging skin have serious repercussions for the health and wellbeing of the organism. Because the skin is at the front line of many external insults throughout life, one could argue that skin aging is largely a result of this continuous environmental attacks. Furthermore, recognition of skin aging as a disease would be advantageous to public health and research efforts. Awareness of strategies to minimize the development of this disease, including a nourishing diet, avoidance of UV, and other measures to promote a functionally responsive integument (including minimizing potentially harmful injectables for short-term cosmetic gain) are of key importance*.

Figure 1: Histologic and histochemical survey of relatively young adult skin (29 years old) from face [chronically sun-exposed (SE)] and abdomen chronically non–sun-exposed (NSE), and relatively old skin (84 and 88 years old). By hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS) staining, there is striking epidermal thinning with loss of the rete ridges in old skin independent of site/chronic UV exposure. In addition, note that old skin, again independent of site/chronic UV exposure, is characterized by less dense, less intensely stained reticular dermal collagen. The diminution of dermal collagen density in old skin is further confirmed by trichrome and elastin stains, which also disclose significant replacement of the uppermost dermis by markedly abnormal elastic fibers (so-called solar elastosis) only in the chronically sun-exposed facial skin, but not in the more photo-protected abdominal skin, of the older individual. Original magnification, ×10.*

HOW DO WE FIGHT BACK THE SKIN AGING DISEASE?

What aging skin really needs are growth factors that would promote collagen production. Even the use of stem cells in plastic surgery is largely with the hope that they will develop into growth factor production
cells (e.g. fibroblasts). Let’s be clear: If you are simply using stem cells, the growth factors that might be made (if any) are less likely to be skin-specific. That is why PRP has gained so much attention! PRP is
produced from your own plasma and contains a high concentration of platelets, growth factors, and active proteins. All these components contribute to tissue regeneration and collagen production.

However, It is still preferable that growth factors have a delivery system, such as liposomes, a process that creates growth factors that are enveloped in an exoskeleton that the cells naturally form. This exoskeleton has many receptors that increase penetration in to cells and activity along with improving stability. Exosome therapy is an advanced treatment that is being proclaimed as the newest frontier in the field of cell therapy. Exosomes are described as extracellular vesicles that are released by stem cells that may be derived from human bone marrow. Exosomes transport genetic information and deliver essential growth factors from platelets to other cells. Exosome therapy is now being used to treat a variety of medical conditions including to reverse the visible signs of aging, as well as increased hair growth in target treatment areas.

* The Pathobiology of Skin Aging . New Insights into an Old Dilemma. Eleanor Russell-Goldman, George F. Murphy. Open ArchivePublished: April 01, 2020DOI.